of HHS physical activity recommendations (p<0.0001 p=0.0002, respectively). 56.5 years, 82% female, 58% with a college education) were less likely to develop word finding difficulties and impaired concentration if they met the Dept. Only the perception of memory difficulties increased over time (R 2=0.64, test for trend, p=0.006). Results:Of 1219 RA subjects, 127 (10.4%) described either poor memory, poor concentration or word finding difficulties as affecting them “often” at the first study visit. Regression models also adjusted for other clinical and demographic variables including DAS-CRP3 score, DMARD and corticosteroid use. of HHS physical activity guidelines of 75 minutes of vigorous or 115 minutes of moderate aerobic activity per week), Body Mass Index (BMI), sleep and depression (MHI-5) in the first year (T0) to the progression of cognitive complaints described as “often” 1 year later (T1).
A repeated measures logistic regression model using pairs of years examined the role of exercise (defined as those meeting the Dept. Self-reported memory, concentration and word-finding difficulties were assessed yearly by questionnaire and graded from “never” to “often”.
Methods: We collected data on joint exams, serologies and detailed clinical, psychological, exercise and functional outcomes over 10 years in a prospective academic RA cohort. We studied the clinical and functional risk factors related to a decrease in perceived cognition function in patients with longstanding RA. Background/Purpose:Modifiable lifestyle factors such as inactivity and obesity contribute to cognitive decline in the general population, but little is known about how these factors may contribute in the setting of a chronic inflammatory condition such as Rheumatoid Arthritis (RA).
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